Teva Discontinues its P-III ENFORCE Study of Fremanezumab for Episodic Cluster Headache

Shots:

• The discontinuation of P-III study is due to the inability of Fremanezumab to meet its 1EPs i.e, reduction in weekly number of cluster headache attacks in 4wks.
• In Jun’18, Teva also discontinued Enforce Program including a chronic cluster headache study assessing Fremanezumab due to its unmeet 1EP i.e, reduction in average no. of cluster headache attacks during the 12-wks. 
• Fremanezumab is a mAb, targeting calcitonin gene-related peptide (CGRP) ligand and block its binding with the receptor and is currently evaluating in P-II trial for post-traumatic headache

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