Eli Lilly and Boehringer Ingelheim Report Cardiovascular Outcomes of Tradjenta (linagliptin) in CAROLINA Study for Type 2 Diabetes

Shots:

• (NCT01243424) study results involve assessing of Tradjenta (5mg, qd) vs glimepiride in patients with type2 diabetes across 43 countries for 6+years
• The CAROLINA study resulted in meeting its 1EPs i.e, occurrence of 3P-MACE (11.8% vs 12.0%), 3P-MACE + 4P-MACE (13.2% vs 13.3%), 2EPs (16.0% vs 10.2%), 77% reduction in risk of hypoglycemia; no new safety signals is observed
• Tradjenta is dipeptidyl peptidase-4 (DPP-4) inhibitor indicated with diet and exercise to reduce blood sugar in adults with type 2 diabetes

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