Janssen Reports Cardiovascular Outcomes of Invokana (canagliflozin) in P-III CREDENCE Study for Type 2 Diabetes and Chronic Kidney Disease

Shots:

• The P-III CREDENCE study results involves assessing of Invokana (100 mg, qd) vs PBO in patients 4,401 patients in ratio (1:1) with T2D and stage II &III CKD prior treated with ACE inhibitors or angiotensin II receptor blockers
• The P-III CREDENCE study results: 20% reduction in risk of CV death, heart stroke & death (9.9% vs. 12.2%); 31% reduction in CV death & hospitalization (8.1% vs 11.5%); 39% reduction in hospitalization for heart (4.0% vs 6.4%); reduces the risk ESKD by 31% & 33% in primary and secondary prevention groups respectively
• Invokana is a therapy for lowering the blood glucose level in adults with T2D and has received FDA’s PR designation and approval for reducing the risk of CV events with T2D in Oct’18

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