ADC Therapeutics and Sophia Genetics Collaborate to Identify Biomarkers in Clinical Study
Shots:
- The companies enter into a collaboration to identify genomic markers associated with clinical response to ADCT-402 (loncastuximab tesirine). ADC Therapeutics is currently assessing ADCT-402 in P-II study in patients with r/r DLBCL
- Sophia Genetic will analyze cell-free DNA (cfDNA) samples extracted from blood patients participating in ADC Therapeutics’ Phase II study utilizing Sophia’s technology, detecting genomic marker with clinical response to ADCT-402
- ADCT-402 is an ADC consisting of humanized mAb, binding to CD19 via linker to PBD dimer toxin and is being evaluated in P-Ib (NCT03684694) & P-Ib (NCT03685344) studies in combination with ibrutinib & durvalumab for R/R DLBCL or MCL & R/R DLBCL, MCL, FL respectively
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