AstraZeneca Reports Results of Farxiga (dapagliflozin) in P-III DAPA-HF Study to Treat Patients with Heart Failure

Shots:

• The P-III DAPA-HF study involves assessing of Farxiga (10mg, qd) vs PBO in patients with heart failure and reduced ejection fraction (HFrEF) (LVEF ≤ 40%), with/without type-2 diabetes on the addition to SOC including ACE inhibitors, ARB, MRAs, beta-blockers and neprilysin inhibitors
• The P-III DAPA-HF study resulted in meeting its 1EPs i.e, reduction in cardiovascular death or worsening of heart failure
• Farxiga is an oral SGLT2 inhibitor, indicated as both monothx. and combination therapy to improve glycemic control, reduction in weight & blood pressure as an adjunct to diet and exercise in patients with T2D, also being studied in patients with HF in DELIVER and DETERMINE (HFrEF and HFpEF) trials respectively

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