Merck’s Keytruda Receives NMPA’s Approval as Monotherapy for 1L Treatment of Advanced Non-Small Cell Lung Cancer with PD-L1 Tumor Expression in China

Shots:

• The NMPA approval is based on the P-III KEYNOTE-042 study assessing Keytruda as monothx. vs CT in patients with stage III NSCLC who were not candidates for surgical resection/definitive chemoradiation/mNSCLC with PD-L1 expression & no prior systemic treatment for mNSCLC including data from the extension of KEYNOTE-042 in Chinese patients
• The extension study results demonstrated improvement in OS in patients whose tumors expressed PD-L1 with a TPS ≥50%, TPS ≥20% and in the entire study population with a TPS ≥1%
• KEYTRUDA is an anti-PD-1 therapy, act blocking the interaction between PD-1 and its ligands, PD-L1 and PD-L2 thus activating T lymphocytes affecting both tumor and healthy cells and is the first anti-PD-1 therapy to be approved as both monothx. & in combination with CT as 1L treatment for NSCLC in China

Click here to­ read full press release/ article | Ref: Merck| Image: Seattle Times