Immuntep, Collaborates with Merck KGaA and Pfizer for Clinical Trial and Supply Agreement for Eftilagimod Alpha with Avelumab

Shots:

• The companies jointly enter into P-I trial evaluating the clinical benefits, combining immune stimulator, Immuntep’s eftilagimod alpha (“efti” or “IMP321”), with Merck and Pfizer’s avelumab. Alliances will jointly develop and commercialize avelumab
• The Institute of Clinical Cancer Research, will sponsor the trial, conducted & involved under ongoing INSIGHT clinical study evaluating P-II dose of efti when combined with avelumab in patients with advanced solid malignancies, assessing its safety, efficacy and tolerability
• Avelumab is a human anti-programmed death ligand-1 (PD-L1) Ab currently being evaluated in JAVELIN clinical development program with seven P-III trials. Eftilagimod is a LAG-3Ig fusion protein currently in P-IIb chemoimmunotherapy for metastatic breast cancer and in P-I combination therapy trial for metastatic melanoma termed TACTI-mel

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