Sorrento Files IND for STI-1499 (COVI-GUARD) in Patients Hospitalized with COVID-19

Shots:

• Sorrento has filed an IND for STI-1499 in patients hospitalized with COVID-19. In preclinical studies, STI-1499 has demonstrated 100% neutralizing effect (in vitro) against the highly contagious D614G mutant strain at a low dose
• Additionally, animal model data confirms the neutralizing profile and high potency of Ab, expected effective dose in human to be at least 5 times lower than current known Abs being assessed in other active trials
• Sorrento has initiated cGMP manufacturing to produce 50,000 doses, expected to be available by the end of 2020, in anticipation of a potential EUA

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