AstraZeneca and MSD Report Five Year Data of Lynparza in P-III SOLO-1 Study for 1L Maintenance Treatment in Patients with BRCA-Mutated Ovarian Cancer

Shots:

• The P-III SOLO-1 study involves assessing of Lynparza (300mg, bid) as a maintenance monothx. vs PBO in 391 patients in a ratio (2:1) with newly diagnosed BRCAm advanced ovarian cancer following 1L Pt.-based CT for ~2yrs. or until disease progression
• Five-year follow-up data demonstrated a 67% reduction in risk of disease progression or death, improvement in PFS (56 vs 13.8mos.), patients remained free from disease progression (48.3% vs 20.5%), the median duration of treatment (24.6 vs 13.9mos.), presented at ESMO 2020
• The P-III SOLO-1 met its 1EPs of PFS in Jun’2018, which formed the basis of approvals in the US, the EU, Japan, China, and other countries. Lynparza is a first-in-class PARP inhibitor acts by targeting DDR in cells/tumors harboring a deficiency in HRR (BRCA1& 2 mutation)

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