Eli Lilly Pauses Enrollment in ACTIV-3 Clinical Trial Due to Safety Concerns

Shots: 

• The independent DSMB recommended pausing the enrollment of the ACTIV-3 clinical trial. The trial is evaluating Lilly’s bamlanivimab (LY-CoV555, 7000mg) + remdesivir as a treatment for COVID-19 in hospitalized patients, and is sponsored by the NIAID
• Lilly trusts the judgment & supports independent DSMB decisions to exercise caution in ensuring the safety of the patients participating in the study. DSMB also considered the impact of the ACTIV-3 study pause on ACTIV-2 and did not recommend any changes to that study’s design or enrollment
• Lilly is testing both single Ab therapy, as well as combinations of Abs as potential therapeutics for COVID-19, across two different patient populations in P-II BLAZE-1, P-III BLAZE-2, and ACTIV-2 study. These trials are not affected by the enrollment pause in the ACTIV-3 clinical trial

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