I-Mab Reports Results of Olamkicept (TJ301) in P-II Study for Ulcerative Colitis

Shots:

• The P-II study involves assessing Olamkicept (300/600mg, q2w, IV) vs PBO in 91 patients in a ratio (1:1:1) who had active UC with a full Mayo score ≥5, a rectal bleeding subscore ≥1, an endoscopy subscore ≥2, and had an inadequate response with conventional UC therapy
• The study met its 1EPs & 2EPs, demonstrating higher clinical response rates after 12wks. of treatment with 600mg dose & more patients achieved clinical remission and mucosal healing respectively. Olamkicept was well tolerated with the acceptable safety profile
• Olamkicept is the only clinical stage selective IL-6 inhibitor that works through the trans-signaling mechanism

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