BMS’ Abecma (Idecabtagene Vicleucel) Receives EC’s Conditional Approval for Relapsed and Refractory Multiple Myeloma

Shots:

• The conditional approval is based on KarMMa study evaluating Abecma (single infusion with a target dose of 420 x 10^6 CAR T cells over a range of 260 to 500 x 10^6 CAR-positive viable T cells) in 128 patients with r/r MM prior treated with 3L therapies including an immunomodulatory agent, a proteasome inhibitor & an anti-CD38 Ab and who are refractory to their last treatment
• Results: ORR (73%); CR rate (33%) & median time to response (1mos.)., m-DoR (10.6mos. & 23 mos. who achieved a CR), responses were rapid & durable with a well-established safety profile
• The company will expand its manufacturing capability of Abecma globally including Leiden & Netherlands. Abecma is a BCMA CAR T cell immunotherapy for adults with MM

Click here to­ read the full press release/ article | Ref: BMS | Image: Fierce Biotech