Eli Lilly Reports Results of Tirzepatide in P-III SURPASS-3 MRI Sub-Study for the Treatment of Type 2 Diabetes

Shots:

The P-III SURPASS-3 MRI sub-study evaluates the effects of tirzepatide (5/10/15mg, qw) vs titrated insulin degludec on LFC, VAT and ASAT in 296 patients with T2D for 52wks.
The study met its 1EPs & 2EPs i.e., (-8.09% from 15.67% vs -3.38% from 16.58%) absolute reduction from baseline in LFC for 10 & 15 mg dose; relative reduction (29.78% – 47.11% vs 11.17%) & patients achieved a 30% reduction in LFC from baseline (66.9%-81.4% vs 32.12%) for 3 doses, overall safety profile was similar to well-established GLP-1 receptor agonist
The therapy showed a reduction in the volume of VAT & ASAT @52wks. Tirzepatide is a dual GIP & GLP-1 receptor agonist

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