Kaleido Reports Results of KB295 in Clinical and Preclinical Studies for the Treatment of Mild-to-Moderate Ulcerative Colitis

Shots:

• The non-IND/CTA study evaluates KB295 in patients with UC. The study evaluates other exploratory assessments including changes in microbiome composition, SCFA levels & biomarkers of inflammation
• The clinical study met its 1EP i.e., patients achieved a reduction in 3 biomarkers includes a reduction in median FCP levels (69%), patients identified as responders (74%), reduction in median Fecal lactoferrin & FimH (69% & 93%). The therapy was well tolerated
• The pre-clinical data from ex-vivo studies showed community-wide changes & modulation of multiple remission-associated taxa, production of SCFA increases. The company plan to start P-II study of KB295, based on pre/clinical data in H1’22

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