Roche Signs a Clinical Program Agreement with Vaccibody to Evaluate VB10.16 + Tecentriq (atezolizumab) for Advanced Cervical Cancer
Roche and AbbVie’s Venclexta (venetoclax) + Gazyva (obinutuzumab) Receive FDA’s Approval for Untreated Chronic Lymphocytic Leukemia
Shots:
- Roche & Vaccibody collaborated to assess the combination of VB10.16 + Tecentriq in P-II, for 50 patients with advanced cervical cancer to evaluate its safety, tolerability, immunogenicity and efficacy
- The combination trial agreement is built upon the trial assessing VB10.16 monothx in patients with precancerous cervical lesion. Vaccibody plans for the onset of P-II for the combination in H2’19
- Tecentriq (atezolizumab) is a mAb inhibiting PD-L1 while blocking its interaction with PD-1 and B7.1 receptor. VB10.16 is a DNA vaccine, targeting HPV16 induced malignancies and is evaluated in P-I/IIa study for patients with pre-cancerous HPV16 induced high grade cervical intraepithelial neoplasia
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